Small intestine microbiota development prevents early-life adiposity via IL-22-mediated intestinal PPARα suppression
Catherine D. Shelton, Camila Bernardo de Brito, Vinícius Dias Nirello, Nicole Kirchoff, Julia Lane, Joanna Olivas, Darian T. Carroll, Derek Armstrong, Matthew W. Rhee, Merrygay N. James, Louise Lantier, Marco Aurélio Ramirez Vinolo, Mariana Xavier Byndloss
This study shows that early-life small intestine microbiota prevents adiposity by suppressing PPARα via IL-22, and antibiotic disruption increases adiposity.
bioRxiv · Jun 12, 2026 · PreprintMicrobiology