Louise Lantier

Hepatocyte UBE4A protects against MASLD/MASH by maintaining ER homeostasis via UBXN4 interaction

This study identifies Ube4A's role in protecting against MASLD/MASH by maintaining ER homeostasis through its interaction with UBXN4, highlighting potential therapeutic targets.

Sulfur amino acid restriction prevents S-adenosylmethionine-driven liver steatosis, hepatocellular carcinoma, and metabolic remodeling in high-fat-fed GNMT-null mice

This study shows that sulfur amino acid restriction prevents liver steatosis and hepatocellular carcinoma in GNMT-null mice fed a high-fat diet by reducing SAM levels and metabolic dysregulation.

Small intestine microbiota development prevents early-life adiposity via IL-22-mediated intestinal PPARα suppression

This study shows that early-life small intestine microbiota prevents adiposity by suppressing PPARα via IL-22, and antibiotic disruption increases adiposity.

Stress unmasks impaired endocrine coordination of glucose metabolism in dystrophin deficiency

This study shows that stress reveals impaired endocrine coordination of glucose metabolism in dystrophin deficiency, with interventions improving glucose control and muscle function.

Dehydration promotes intracellular lipid synthesis and accumulation

This study shows dehydration increases intracellular lipid synthesis and accumulation by promoting glutamine oxidation and mitochondrial metabolic remodeling.

A high-resolution mass spectrometry-based method for quantifying insulin-stimulated glucose uptake in mice following an intraperitoneal injection of tracer

This paper develops and validates a mass spectrometry-based method to measure insulin-stimulated tissue-specific glucose clearance in mice without radiolabels or catheters.

Alpha Parvin Promotes Glucose Uptake and Metabolism in Skeletal Muscle with Minimal Influence on Hepatic Insulin Sensitivity

This study shows that Parvin in skeletal muscle is essential for insulin-stimulated glucose uptake and mitochondrial function, while having little effect on liver insulin sensitivity.

Increased cGMP improves microvascular exercise training adaptations independent of endothelial nitric oxide synthase

This study shows that sildenafil enhances microvascular adaptations to exercise training in obese mice, independent of endothelial nitric oxide synthase function.

High fat diet but not glucocorticoid-induced obesity results in fatty liver

This study compares the effects of high-fat diet and glucocorticoid-induced obesity on metabolic outcomes, finding that the latter prevents fatty liver despite similar adiposity.

Systemic inhibition of de novo purine biosynthesis prevents weight gain and improves metabolic health by increasing thermogenesis and decreasing food intake

This study shows that inhibiting purine biosynthesis with mizoribine prevents weight gain and improves metabolic health in mice on a high-fat diet by increasing thermogenesis and reducing food intake.

Endothelial β1 Integrins are Necessary for Microvascular Function and Glucose Uptake

This study shows that endothelial β1 integrins are essential for microvascular function and glucose uptake during insulin stimulation.

Validation of a refined protocol for mouse oral glucose tolerance testing without gavage

This paper validates a refined, non-invasive method for mouse oral glucose tolerance testing that avoids gavage, showing reduced stress and improved consistency in glucose tolerance measurements.

CalR: A Web-based Analysis Tool for Indirect Calorimetry Experiments

CalR is a web-based tool for analyzing indirect calorimetry data, offering statistical analysis, visualization, and standardized output to improve reproducibility and efficiency in metabolic experiments.