Hepatic iNKT cells facilitate colorectal cancer metastasis by inducing a fibrotic niche in the liver
Marc Nater, Michael David Brügger, Virginia Cecconi, Paulo Pereira, Geo Forni, Hakan Köksal, Despoina Dimakou, Michael Herbst, Anna Laura Calvanese, Giulia Lucchiari, Christoph Schneider, Tomáš Valenta, Maries F. van den Broek
This study shows hepatic iNKT cells promote colorectal cancer metastasis by creating a fibrotic niche through IL-4 and IL-13 signaling.
iScience · Apr 8, 2025Peer-reviewedImmunology