Tomáš Valenta

This study identifies Wnt7b as a critical autocrine WNT ligand required for survival of BRAF-mutant colorectal cancer organoids and shows its association with poor patient survival in human tumors.

This study identifies APOA1 as a marker of a late fetal colonic epithelial state that reappears after injury, linking it to colonic maturation and injury responses through interactions with WNT5A and regulation by HOXB7.

The paper integrates single-cell data from CRC patients to identify immune subtypes and neutrophil phenotypes, revealing their spatial organization and tumor-induced changes.

RoCK and ROI improves single-cell transcriptomics by targeting specific transcripts and regions, enhancing detection of critical biological features.

This study shows hepatic iNKT cells promote colorectal cancer metastasis by creating a fibrotic niche through IL-4 and IL-13 signaling.

The paper develops ENS-Rich Assembloids to study enteric nervous system dynamics, revealing glial support mechanisms and PTN signaling in inflammation and regeneration.

This study shows eosinophils inhibit CRC metastasis by blocking SPP1+ macrophage differentiation, using transcriptomics and a murine model.

This study introduces oncoembryology to identify SoxC transcription factors as regulators of colon development and cancer, showing their role in tumor growth and metastasis.

This study investigates the role of Tcf4 in intestinal epithelial regeneration and tumorigenesis using mouse models and RNA sequencing, finding that Tcf4 loss shifts cell lineage from Paneth to goblet cells and affects tumor cell phenotypes.

The paper introduces a CRISPR/Cas9-based mouse model for lineage tracing and gene manipulation in Lgr5+ intestinal stem cells without affecting endogenous Lgr5 function.