Michael David Brügger

APOA1 links a late fetal epithelial program to colonic maturation and injury responses

This study identifies APOA1 as a marker of a late fetal colonic epithelial state that reappears after injury, linking it to colonic maturation and injury responses through interactions with WNT5A and regulation by HOXB7.

RoCK and ROI: Single-cell transcriptomics with multiplexed enrichment of selected transcripts and region-specific sequencing

RoCK and ROI improves single-cell transcriptomics by targeting specific transcripts and regions, enhancing detection of critical biological features.

Hepatic iNKT cells facilitate colorectal cancer metastasis by inducing a fibrotic niche in the liver

This study shows hepatic iNKT cells promote colorectal cancer metastasis by creating a fibrotic niche through IL-4 and IL-13 signaling.

Eosinophils restrict CRC metastasis by inhibiting pro-tumorigenic SPP1+ macrophage differentiation

This study shows eosinophils inhibit CRC metastasis by blocking SPP1+ macrophage differentiation, using transcriptomics and a murine model.

An oncoembryology approach uncovers SoxC-driven regulation of colon development and cancer

This study introduces oncoembryology to identify SoxC transcription factors as regulators of colon development and cancer, showing their role in tumor growth and metastasis.

Manipulating the murine Lgr5 locus using a rapid, efficient and flexible CRISPR/Cas9 pipeline

The paper introduces a CRISPR/Cas9-based mouse model for lineage tracing and gene manipulation in Lgr5+ intestinal stem cells without affecting endogenous Lgr5 function.