A structure-guided antibody detects SOD1 oligomers in diverse ALS genotypes.
Smriti Sangwan, Hannah E. Rieder, Destaye M. Moore, Négar Khanlou, Bennett G. Novitch, Mark Geisberg, David S Eisenberg
This study develops a structure-guided antibody that detects SOD1 oligomers in various ALS genotypes and shows its ability to alleviate cytotoxic effects in cell cultures.
bioRxiv · May 5, 2025 · PreprintNeuroscience