Bennett G. Novitch

This study uses human brain assembloids to model how a genetic epilepsy syndrome affects cortical and hippocampal networks differently, revealing distinct dysfunction patterns.

This study develops a structure-guided antibody that detects SOD1 oligomers in various ALS genotypes and shows its ability to alleviate cytotoxic effects in cell cultures.

The paper uses pseudotime analysis of single-cell RNA-Seq data from mouse dorsal spinal interneurons to identify novel regulators and lineage relationships between interneuron populations.

This study identifies Prdm16 and Vcam1 as regulators of postnatal radial glia disappearance and the termination of cortical neurogenesis.

This study shows that Foxp1 loss increases angiogenesis and hypoxia in radial glia, altering their metabolic state and neurogenic capacity.

This study identifies neural oscillations and epileptiform changes in human brain organoids derived from MECP2 mutant patients using calcium imaging and extracellular recordings.

This study identifies Foxp1's role in maintaining apical radial glia identity and promoting deep layer cortical neuron production during neocortex development.

This study shows that maintaining human pluripotent stem cells with feeders improves cortical organoid formation by activating TGFβ signaling and naive pluripotency genes, which can be mimicked with TGFβ growth factors.

The paper uses single cell transcriptomics to study Olig2 and Hes regulatory dynamics during motor neuron differentiation, revealing Olig2's role in repressing Hes5 and coordinating differentiation timing.