Caroline Alayne Pearson

This study shows mitochondrial dysfunction and oxidative stress occur before neuronal loss in DRPLA patient-derived neurons, and phenylbutyrate treatment improves survival.

This paper demonstrates that vitrification can effectively cryopreserve human cortical organoids, maintaining their structure, cell type composition, and function.

This study shows that Foxp1 loss increases angiogenesis and hypoxia in radial glia, altering their metabolic state and neurogenic capacity.

This study identifies Foxp1's role in maintaining apical radial glia identity and promoting deep layer cortical neuron production during neocortex development.

The paper uses single cell transcriptomics to study Olig2 and Hes regulatory dynamics during motor neuron differentiation, revealing Olig2's role in repressing Hes5 and coordinating differentiation timing.