SIX1 cooperates with RUNX1 and SMAD4 in cell fate commitment of Müllerian duct epithelium
Jumpei Terakawa, Vanida Ann Serna, Devi M. Nair, Shigeru Sato, Kiyoshi Kawakami, Sally Radovick, Pascal Maire, Takeshi Kurita
This paper identifies SIX1 as a critical transcription factor downstream of mesenchymal signals that cooperates with RUNX1 and SMAD4 to regulate {Delta}Np63 expression in Mullerian duct epithelium, leading to vaginal stratified squamous epithelium formation and preventing adenosis.
Cell Death and Differentiation · Jun 22, 2020Peer-reviewedDevelopmental Biology