Developmental BiologyCell Death and DifferentiationPeer-reviewed
SIX1 cooperates with RUNX1 and SMAD4 in cell fate commitment of Müllerian duct epithelium
Jumpei Terakawa, Vanida Ann Serna, Devi M. Nair…·Takeshi Kurita
This paper identifies SIX1 as a critical transcription factor downstream of mesenchymal signals that cooperates with RUNX1 and SMAD4 to regulate {Delta}Np63 expression in Mullerian duct epithelium, leading to vaginal stratified squamous epithelium formation and preventing adenosis.
18 citations