A dual sensor regulates P-glycoproteins structural plasticity
Michael Kamel, Jan-Hannes Schäfer, Valeria Jaramillo‐Martinez, Nghi N.B. Tran, Devin L Mangold, Dmitry Shvarev, Kilian Schnelle, Kristian Parey, Dovile Januliene, Ina L. Urbatsch, Arne Moeller
The paper uses cryo-EM to study P-glycoprotein in different environments, revealing distinct roles of transmembrane helices 4 and 10 in its functional plasticity.
bioRxiv · Mar 15, 2026 · PreprintMolecular Biology