Arne Moeller

Cholesterol transport cycle of human ABCA2

This study reports cryo-EM structures of human ABCA2, revealing its cholesterol transport mechanism and novel conformational changes.

A dual sensor regulates P-glycoproteins structural plasticity

The paper uses cryo-EM to study P-glycoprotein in different environments, revealing distinct roles of transmembrane helices 4 and 10 in its functional plasticity.

Ultrastructural organization and dynamics of TIRAP filaments

This study determines the structure of TIRAP filaments and identifies the role of the N-terminal PBM in regulating their assembly and function at the plasma membrane.

Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned

This study compares the structural and functional mechanisms of Mon1-Ccz1 and Fuzzy-Inturned RabGEFs to explain their target specificity and membrane recruitment.

The ABC transporter MsbA in a dozen environments

This study systematically analyzes the conformational spectrum of the bacterial ABC transporter MsbA in twelve different membrane mimetics using cryo-EM, revealing environment-specific structural responses.

Cryo-EM structure of cell-free synthesized human histamine H2 receptor coupled to heterotrimeric Gs protein in lipid nanodisc environment

The paper presents the cryo-EM structure of the human histamine H2 receptor complexed with Gs protein in lipid nanodiscs, revealing insights into ligand binding and G protein coupling mechanisms.

Stabilization of α-synuclein oligomers using formaldehyde

This study stabilizes α-synuclein oligomers using formaldehyde, preserving their structure and function for use as biomarkers in Parkinson's disease research.

Structure and autoregulation of a P4-ATPase lipid flippase

The paper determines the structures of the P4-ATPase Drs2p-Cdc50p using cryo-EM, revealing autoinhibition and PI4P-dependent activation mechanisms.