Multi-organ imaging-derived polygenic indexes for brain and body health
Xiaochen Yang, Patrick F. Sullivan, Bingxuan Li, Zirui Fan, Dezheng Ding, Juan Shu, Yuxin Guo, Peristera Paschou, Jingxuan Bao, Li Shen, Marylyn DeRiggi Ritchie, Gideon Nave, Michael L. Platt, Tengfei Li, Hongtu Zhu B, Bingxin Zhao
The paper uses genetic data to predict imaging-derived phenotypes from the UK Biobank, creating polygenic scores that identify disease risk in external cohorts.
medRxiv · Apr 18, 2023 · PreprintGenetic & Genomic Medicine