Peristera Paschou

Leveraging Shared Genetic Architecture Between Psychiatric and Other Medical Disorders Increases Power and Reveals Novel Psychiatric Risk Loci

The paper identifies shared genetic architectures between psychiatric and non-psychiatric disorders, revealing novel psychiatric risk loci through cross-trait analyses.

Multi-Ancestry GWAS of Neuroticism Identifies Novel Loci and Enhances Fine-Mapping Resolution

This study performs a multi-ancestry GWAS of neuroticism, identifying novel loci and improving fine-mapping resolution across diverse populations.

Limited overlap between genetic effects on disease susceptibility and disease survival

The paper compares genetic effects on disease susceptibility and progression, finding limited overlap and suggesting larger samples or different progression measures are needed.

Contextualizing molecular and structural aging across human organs

The paper investigates organ-specific and modality-specific aging clocks using proteomic and imaging data, revealing distinct biological processes and their roles in age-related diseases.

Neuropathology-based GWAS for Alzheimer's disease reveals novel susceptibility loci and highlights sex-specific pathways

Multiomic approach and Mendelian randomization analysis identify causal associations between blood biomarkers and subcortical brain structure volumes.

The paper uses Mendelian randomization to identify causal links between blood biomarkers and subcortical brain structure volumes, finding associations with specific proteins, metabolites, and biological processes.

Multi-organ imaging-derived polygenic indexes for brain and body health

The paper uses genetic data to predict imaging-derived phenotypes from the UK Biobank, creating polygenic scores that identify disease risk in external cohorts.

PheWAS and cross-disorder analyses reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders.

The paper conducts a PRS-PheWAS analysis of 11 autoimmune disorders using UK Biobank data, identifying 554 significant phenotypic associations and five genetic factors.

The role of sleep in the human brain and body: insights from multi-organ imaging genetics

This study identifies genetic overlaps between sleep traits and multi-organ imaging biomarkers, showing strong genetic links between sleep and psychiatric disorders.

Reconstructing SNP Allele and Genotype Frequencies from GWAS Summary Statistics

This paper introduces a framework to reconstruct SNP allele and genotype frequencies from GWAS summary statistics and presents three applications, showing high performance in power and error control.

Phenomic Network Analysis for Depression Reveals Comorbidity Architecture, Genomic Relationships, and Pleiotropic Variants

This study uses UK Biobank data to analyze genetic and phenotypic connections between depression and other traits, identifying causal relationships and pleiotropic variants.

Genome-wide Association Study identifies two novel loci for Gilles de la Tourette Syndrome

This study identifies two novel genetic loci associated with Tourette Syndrome through a genome-wide meta-analysis and integrates functional data to implicate specific genes.

Synaptic processes and immune-related pathways implicated in Tourette Syndrome

This study identifies gene sets associated with Tourette Syndrome using genome-wide data, highlighting synaptic and immune-related pathways.

Integrating linguistics, social structure, and geography to model genetic diversity within India

The paper models genetic diversity in India by integrating geography, language, and social structure, finding language and social factors most influential in shaping genetic patterns.

CluStrat: a structure informed clustering strategy for population stratification

CluStrat improves population stratification correction in GWAS by using clustering and randomized regression, identifying more true causal variants than PCA-based methods.

Cross-disorder GWAS meta-analysis for Attention Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and Tourette Syndrome

This study performs a cross-disorder GWAS meta-analysis of ADHD, ASD, OCD, and TS, identifying 297 genome-wide significant variants and 21 genes associated with shared genetic risk.

Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe

The paper analyzes the genetic structure of modern-day Italians to reveal ancient and archaic ancestries shaping Southern European populations and Neanderthal DNA distribution.

Concordance Of Genetic Variation That Increases Risk For Tourette Syndrome And That Influences Its Underlying Neurocircuitry

This study identifies genetic overlaps between Tourette Syndrome risk and subcortical brain volumes using GWAS and pleiotropy analysis.

TECPR2 a positive regulator of autophagy is implicated in healthy brain ageing

The paper identifies a genetic variant in TECPR2 associated with healthy brain aging and neuroprotection against Alzheimer's disease.