Author

Yuxin Guo

Purdue University West Lafayette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Genetic & Genomic Medicine· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:imaging· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Bingxin ZhaoiD· 3 shared Juan ShuiD· 3 shared Peristera PaschouiD· 3 shared Xiaochen YangiD· 3 shared Zirui FaniD· 3 shared Bingxuan LiiD· 2 shared Hongtu Zhu BiD· 2 shared Jinjie Lin· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Bingxin ZhaoORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rational design of respiratory syncytial virus dimeric F-subunit vaccines in protein and mRNA forms

Jing Li, Xuehui Ma, Zepeng Xu, Wenjing Guo, Ruchao Peng, Yuqin Zhang, Yumin Meng, Jianrui Zhao, Qiyue Wang, Shuang Li, Jiaqin Chen, Yuxin Guo, Xuancheng Lu, Qingling Wang, Yushuang Guo, , Jianxun Qi

This study designs and tests dimeric RSV F-subunit vaccines in protein and mRNA forms, showing enhanced immunogenicity and protection against RSV infection in rodent models.

EBioMedicine · Aug 30, 2025Peer-reviewedImmunology

Contextualizing molecular and structural aging across human organs

Juan Shu, Yuxin Guo, Julio A. Chirinos, Zirui Fan, Yilin Yang, Yujue Li, Xiaochen Yang, Cameron Beeche, Buxin Su, Iris Horng, Rong Zheng, Peristera Paschou, Li‐San Wang, Joan M. O’Brien, Ruben C. Gur, , Bingxin Zhao

The paper investigates organ-specific and modality-specific aging clocks using proteomic and imaging data, revealing distinct biological processes and their roles in age-related diseases.

medRxiv · May 26, 2025 · PreprintGenetic & Genomic Medicine

Multi-organ imaging-derived polygenic indexes for brain and body health

Xiaochen Yang, Patrick F. Sullivan, Bingxuan Li, Zirui Fan, Dezheng Ding, Juan Shu, Yuxin Guo, Peristera Paschou, Jingxuan Bao, Li Shen, Marylyn DeRiggi Ritchie, Gideon Nave, Michael L. Platt, Tengfei Li, Hongtu Zhu B, Bingxin Zhao

The paper uses genetic data to predict imaging-derived phenotypes from the UK Biobank, creating polygenic scores that identify disease risk in external cohorts.

medRxiv · Apr 18, 2023 · PreprintGenetic & Genomic Medicine

The role of sleep in the human brain and body: insights from multi-organ imaging genetics

Zirui Fan, Yilin Yang, Yuxin Guo, Yujue Li, Juan Shu, Xiaochen Yang, Bingxuan Li, Jinjie Lin, Qianwen Wang, Carolyn Gibson, Peristera Paschou, Tengfei Li, Philip Gehrman, Hongtu Zhu B, Bingxin Zhao

This study identifies genetic overlaps between sleep traits and multi-organ imaging biomarkers, showing strong genetic links between sleep and psychiatric disorders.

medRxiv · Sep 8, 2022 · PreprintGenetic & Genomic Medicine