Amyloid-beta is present in the spinal cord of APP/PS1 mice and may contribute to neuropathology manifesting as lower urinary tract dysfunction
Sophia M. Vrba, Ajinkya R. Limkar, Kimberly P. Keil, Jeffrey Nirschl, Collin James Laaker, Dhruv Bansal, Simon FW Ordonez, Erin G. Brooks, Jeffrey Helgager, Mariana Pehar, Mátyás Sándor, William A. Ricke, Zsuzsanna Fábry
This study shows that amyloid-beta accumulates in the spinal cord of AD mice and is linked to lower urinary tract dysfunction through altered neuronal signaling.
bioRxiv · Jul 13, 2026 · PreprintNeuroscience