Jeffrey Nirschl

This study shows that amyloid-beta accumulates in the spinal cord of AD mice and is linked to lower urinary tract dysfunction through altered neuronal signaling.

CellFluxV2 is an image-generative model that predicts cell morphology changes under perturbations, achieving higher image fidelity than baselines and enabling batch-effect correction and cell-state interpolation.

This paper introduces ComSLI, a method to map fiber networks in histology without sample preparation, showing its application across tissues and diseases.

This paper develops a pipeline for precise MRI-histology coregistration using blockface imaging, achieving high alignment accuracy for neurodegenerative disease research.

This paper introduces O2-VAE, an orientation-invariant representation learning method for morphologic profiling of cells and organelles, improving clustering and outlier detection.