William A. Ricke

Profiling crystal engineered ligands for targeting treatment resistant androgen receptors

This study develops and evaluates crystal-engineered ligands (CBs) for targeting treatment-resistant androgen receptors in prostate cancer, showing their potential as novel therapeutic agents.

Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice

This study shows that lifelong dietary valine restriction improves healthspan and extends lifespan in male mice but not females, with distinct molecular effects in different tissues.

Amyloid-beta is present in the spinal cord of APP/PS1 mice and may contribute to neuropathology manifesting as lower urinary tract dysfunction

This study shows that amyloid-beta accumulates in the spinal cord of AD mice and is linked to lower urinary tract dysfunction through altered neuronal signaling.

Ex vivo high-resolution nano-computed tomography imaging reveals spatial architecture of the adult male mouse lower urogenital tract

This study uses nanoCT imaging to analyze the murine lower urogenital tract anatomy, revealing structural details relevant to understanding BPH and improving mouse model translational relevance.

Amyloid-beta deposition and reduced drainage at the cribriform plate lymphatics in APP/PS1 mouse model of Alzheimer's Disease

This study shows that in 24-month-old APP/PS1 mice, cribriform plate lymphatics have reduced CSF efflux and A{beta} accumulation, along with inflammation and lymphatic atrophy.