Cancer BiologybioRxiv
Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.
Lucas D. Caeiro, Yuichiro Nakata, Rodrigo L. Borges…·Lluís Morey
This study shows that H3K36M mutations in HNSCC create a therapeutic window by altering H3K27me3 levels, making tumors sensitive to PARP1/2 inhibitors or their combination with H3K27me3-upregulating agents.
12 citations