Blood-based Transcriptomics Reveal Sex- and Amyloid-Modulated Biology of Plasma pTau217 in Preclinical Alzheimer's Disease
Mabel Seto, Hannah M Klinger, Michelle J. Clifton, Vaibhav A. Janve, Jane A. Brown, Colin J. Birkenbihl, Gillian Coughlan, Diana L Townsend, Ting‐Chen Wang, Michael J Properzi, Bernard Jimmy Hanseeuw, Jasmeer P. Chhatwal, Hyun‐Sik Yang, Yanling Wang, Philip L. De Jager, , Rachel F. Buckley
The paper identifies gene associations with plasma pTau217 in preclinical Alzheimer's disease, showing modulation by APOEε4, Aβ-PET, and sex, with X-linked genes playing a role.
bioRxiv · Nov 21, 2025 · PreprintNeuroscience