Author

Rachel F. Buckley

Harvard UniversityORCID 0000-0002-5356-5537Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Approach:deep learning· 1

Frequent Co-Authors

Timothy J. HohmaniD· 5 shared Logan C. DumitrescuiD· 4 shared Andrew J. SaykiniD· 3 shared Elizabeth C. MorminoiD· 3 shared Reisa Anne SperlingiD· 3 shared Angela Lee JeffersoniD· 2 shared Annah M. Moore· 2 shared David A. Bennett· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersNeuroscience

Timothy J. HohmanORCID

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Author profile →

5 papers

Recent·Most cited

Continuous amyloid staging complements global amyloid burden in early Alzheimer's disease

Haoyuan Liu, Mingzhao Tong, Shiaofen Fang, Elizabeth C. Mormino, Reisa Anne Sperling, Paul Aisen, Rachel F. Buckley, Paul Crane, Timothy J. Hohman, Andrew J. Saykin, Jingwen Yan, For the Alzheimers Disease Neuroimaging Initiative

This paper develops a continuous amyloid staging score from regional amyloid PET to improve early Alzheimer's disease staging and cognitive risk stratification.

bioRxiv · Oct 11, 2026 · PreprintNeuroscience

Blood-based Transcriptomics Reveal Sex- and Amyloid-Modulated Biology of Plasma pTau217 in Preclinical Alzheimer's Disease

Mabel Seto, Hannah M Klinger, Michelle J. Clifton, Vaibhav A. Janve, Jane A. Brown, Colin J. Birkenbihl, Gillian Coughlan, Diana L Townsend, Ting‐Chen Wang, Michael J Properzi, Bernard Jimmy Hanseeuw, Jasmeer P. Chhatwal, Hyun‐Sik Yang, Yanling Wang, Philip L. De Jager, , Rachel F. Buckley

The paper identifies gene associations with plasma pTau217 in preclinical Alzheimer's disease, showing modulation by APOEε4, Aβ-PET, and sex, with X-linked genes playing a role.

bioRxiv · Nov 21, 2025 · PreprintNeuroscience

Sex-specific Associations of Gene Expression with Alzheimer's Disease Neuropathology and Ante-mortem Cognitive Performance

Mabel Seto, Michelle J. Clifton, Melisa Lara Gomez, Gillian Coughlan, Katherine A. Gifford, Angela Lee Jefferson, Philip L. De Jager, David A. Bennett, Yanling Wang, Lisa Laverne Barnes, Julie A. Schneider, Timothy J. Hohman, Rachel F. Buckley, Logan C. Dumitrescu

The paper examines sex-specific gene expression associations with Alzheimer's disease neuropathology and cognitive performance using bulk transcriptomic data from 767 individuals.

Nature Communications · Oct 27, 2025Peer-reviewedNeuroscience

Genetic Variants and Functional Pathways Associated with Resilience to Alzheimer's Disease

Logan C. Dumitrescu, Emily R. Mahoney, Shubhabrata Mukherjee, Michael L. Lee, William S. Bush, Corinne D. Engelman, Qiongshi Lu, David W. Fardo, Emily H. Trittschuh, Jesse B Mez, Catherine Cook Kaczorowski, Hector Hernandez Saucedo, Keith F. Widaman, Rachel F. Buckley, Michael J Properzi, , Timothy J. Hohman

This study identifies genetic variants and pathways associated with cognitive resilience to Alzheimer's disease, finding a novel locus linked to bile acid metabolism and methylation changes.

Brain · Jun 16, 2020Peer-reviewedGenetics

A/T/N polygenic risk score for cognitive decline in old age

Annah M. Moore, Teresa Jenica Filshtein, Logan C. Dumitrescu, Amal Harrati, Fanny M. Elahi, Elizabeth C. Mormino, Yuetiva K. Deming, Brian W. Kunkle, Dan Mungas, Trey Hedden, Liana G. Apostolova, Andrew J. Saykin, Danai Chasioti, Qiongshi Lu, Jessica Kiri Dennis, , Timothy J. Hohman

The paper develops a polygenic risk score integrating AD biomarkers and shows it better predicts cognitive decline than a clinical AD-based PRS.

bioRxiv · Nov 12, 2019 · PreprintGenomics