Virus-free continuous directed evolution in human cells using somatic hypermutation
Stanley Bram, Diego J. Orea, Graeme Lindsey, Soyu Zi, Jordan Quenneville, Hui Xu, Sarah Leach, Jenna J. Guthmiller, Angad P. Mehta
This paper develops a continuous directed evolution platform in human B cells using somatic hypermutation to evolve proteins with diverse mutations.
bioRxiv · Dec 24, 2024 · PreprintSynthetic Biology