Jenna J. Guthmiller

The paper analyzes antigenic drift in the H1 hemagglutinin lateral patch across time and species using monoclonal antibodies to identify mutations that evade immune targeting.

This study characterizes antibody responses to H3 influenza A virus in mallard ducks, revealing unique features compared to human antibodies and highlighting gene conversion in antibody evolution.

This study introduces oPool+ display, a high-throughput platform for synthesizing and characterizing natively paired antibodies, demonstrating its application in analyzing influenza HA antibodies.

The paper investigates H5N1 transmission on dairy farms by sampling air, wastewater, and milk, finding infectious virus in air and wastewater, viral RNA in cow breath, and subclinical infections in cows.

This study identifies a single mutation in H5N1 viruses from dairy cows that increases receptor binding breadth to avian receptors, suggesting potential for expanded host range.

This paper develops a continuous directed evolution platform in human B cells using somatic hypermutation to evolve proteins with diverse mutations.

The paper introduces MAGMA-seq, a technology for quantitative analysis of antibody sequence-function relationships, demonstrating its application in mapping antibody development pathways and identifying binding determinants.