A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects
Irfan S. Kathiriya, Martin H. Dominguez, Kavitha S. Rao, Jonathon M. Muncie, W. Patrick Devine, Kevin M. Hu, Swetansu K. Hota, Bayardo I. Garay, Diego Quintero, Piyush Goyal, Megan N. Matthews, Reuben Thomas, Tatyana Sukonnik, Dario Miguel-Perez, Sarah A. B. Winchester, , Benoit G. Bruneau
The paper identifies Tbx5 as a gene critical for forming a compartment boundary in the interventricular septum, and shows its disruption leads to congenital heart defects.
Nature Cardiovascular Research · Dec 29, 2025Peer-reviewedDevelopmental Biology