Jonathon M. Muncie

The paper identifies Tbx5 as a gene critical for forming a compartment boundary in the interventricular septum, and shows its disruption leads to congenital heart defects.

This study identifies MEF2C-dependent gene regulatory networks in specific heart segments and shows their role in heart tube morphogenesis using multi-omics data and deep learning.

This study uses live embryo imaging to show how mesoderm gradients guide heart development through spatial and temporal morphodynamics.

The paper shows engineered substrates promoting cell-cell adhesion drive gastrulation-like self-organization in hESCs by enhancing cell tension and Wnt signaling to specify mesoderm.