Microglial CX3CR1I249/M280 variant limits neurogenesis and remyelination in cuprizone-induced multiple sclerosis model
Andrew S. Mendiola, Kaira A. Church, Sandra M. Cardona, Difernando Vanegas, Shannon A. Garcia, Wendy B. Macklin, Sérgio A. Lira, Richard M. Ransohoff, Erzsebet Kokovay, Chin‐Hsing Annie Lin, Astrid E. Cardona
This study shows that the hCX3CR1I249/M280 variant impairs microglial function, reducing neurogenesis and remyelination in a multiple sclerosis model.
bioRxiv · Jun 6, 2021 · PreprintNeuroscience