Author

Richard M. Ransohoff

ORCID 0000-0003-0175-6910Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Sérgio A. LiraiD· 2 shared Agnes J. VialeiD· 1 shared Ana BadimoniD· 1 shared Andi WangzhouiD· 1 shared Andrea ReboldiiD· 1 shared Andrew R. TapperiD· 1 shared Andrew S. MendiolaiD· 1 shared Ann Baako· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersNeuroscience

Sérgio A. LiraORCID

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5 papers

Recent·Most cited

Commensal Escherichia coli colonization triggers Peyer's patch development

Romana Raphaela Gerner, Gregory T. Walker, Suzi M. Klaus, Karine Melchior, Suzana Hossain, Kareem Siada, Chia-Yun Hsu, Francisco Javier Albicoro, William Santus, Rasika Patkar, Marvic Carrillo Terrazas, Grant J. Norton, Flavian Thelen, Araceli Pérez-López, Purnima Sharma, , Manuela Raffatellu

This study identifies Escherichia coli as a key driver of B cell accumulation in Peyer's patches via CXCR2-dependent mechanisms involving curli amyloid fibers and TLR2 signaling.

bioRxiv · Oct 6, 2025 · PreprintMicrobiology

A microglia clonal inflammatory disorder in Alzheimer's Disease

Rocío Vicario, Stamatina Fragkogianni, Leslie Weber, Tomi Lazarov, Yang Hu, Samantha Y. Hayashi, Barbara P. Craddock, Nicholas D. Socci, Araitz Alberdi, Ann Baako, Oyku Ay, Masato Ogishi, Estibaliz Lopez-Rodrigo, Rajya L. Kappagantula, Agnes J. Viale, , Frédéric Geissmann

The paper identifies microglia-specific somatic clones with pathogenic variants in Alzheimer's Disease patients that drive neuro-inflammation through the MAPK pathway.

eLife · Jan 29, 2025Peer-reviewedNeuroscience

Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer's disease

Beika Zhu, Andi Wangzhou, Diankun Yu, Tao Li, Rachael Schmidt, Stacy L. De Florencio, Lauren Chao, Yonatan Perez, Lea T. Grinberg, Salvatore Spina, Richard M. Ransohoff, Arnold R. Kriegstein, William W. Seeley, Tomasz Jan Nowakowski, Xianhua Piao

This study shows that ADGRG1 in microglia helps protect against Alzheimer's disease by improving amyloid clearance and reducing pathology.

bioRxiv · Oct 15, 2024 · PreprintNeuroscience

Microglial CX3CR1I249/M280 variant limits neurogenesis and remyelination in cuprizone-induced multiple sclerosis model

Andrew S. Mendiola, Kaira A. Church, Sandra M. Cardona, Difernando Vanegas, Shannon A. Garcia, Wendy B. Macklin, Sérgio A. Lira, Richard M. Ransohoff, Erzsebet Kokovay, Chin‐Hsing Annie Lin, Astrid E. Cardona

This study shows that the hCX3CR1I249/M280 variant impairs microglial function, reducing neurogenesis and remyelination in a multiple sclerosis model.

bioRxiv · Jun 6, 2021 · PreprintNeuroscience

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

Georgia Gunner, Lucas Cheadle, Kasey M. Johnson, Pinar Ayata, Ana Badimon, Erica Mondo, M. Aurel Nagy, Liwang Liu, Shane M. Bemiller, Ki-Wook Kim, Sérgio A. Lira, Bruce T. Lamb, Andrew R. Tapper, Richard M. Ransohoff, Michael E. Greenberg, , Dorothy P. Schafer

This study shows that sensory lesioning causes microglia to eliminate synapses through ADAM10 and fractalkine signaling, revealing a neuron-to-microglia pathway for synaptic remodeling.

Nature Neuroscience · Jun 17, 2019Peer-reviewedNeuroscience