Wendy B. Macklin

Microglia drive demyelination via multiple sclerosis antibodies and BTK signaling

This study shows microglia drive myelin loss in MS through autoantibodies and BTK signaling, with implications for therapeutic targeting.

Language Model Embedding Classifiers Enable Identification of Multiple Sclerosis-Associated BCRs and Repertoires

The paper develops a language model to identify MS-associated BCRs by embedding BCR sequences and classifying them for disease association.

Early developmental neuronal activity inhibits oligodendrocyte differentiation through AMPA receptor activation

The paper shows that early neuronal activity inhibits oligodendrocyte differentiation via AMPA receptor signaling in mice, with reduced activity promoting differentiation.

Early myelination involves the dynamic and repetitive ensheathment of axons which resolves through a low and consistent stabilization rate

The paper quantifies axon ensheathment dynamics in zebrafish oligodendrocytes, finding a high and consistent sheath destabilization rate despite variable initiation.

Chronic Changes In Oligodendrocyte Sub-Populations After Middle Cerebral Artery Occlusion in Neonatal Mice.

This study uses scRNA-seq to analyze oligodendrocyte gene expression changes in a neonatal mouse model of stroke, identifying a reactive subset that may be a target for white matter repair.

mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system

This study shows that deleting mTORC2 in oligodendrocyte progenitor cells causes hypomyelination specifically in the corpus callosum, but not the spinal cord.

Signatures for Viral Infection and Inflammation in the Proximal Olfactory System in Familial Alzheimer's Disease

The paper identifies viral infection and inflammation signatures in the olfactory system of familial Alzheimer's disease patients, suggesting their role in disease progression.

Excitable axonal domains adapt to sensory deprivation in the olfactory system

This study shows that unilateral sensory deprivation leads to system-wide adaptations in mitral cell axons and physiology in the olfactory system.

Microglial CX3CR1I249/M280 variant limits neurogenesis and remyelination in cuprizone-induced multiple sclerosis model

This study shows that the hCX3CR1I249/M280 variant impairs microglial function, reducing neurogenesis and remyelination in a multiple sclerosis model.

Single-cell Sequencing Reveals Brain/Spinal Cord Oligodendrocyte Precursor Heterogeneity and Requirement for mTOR in Cholesterol Biosynthesis and Myelin Maintenance

The paper uses single-cell sequencing to show brain and spinal cord oligodendroglia are transcriptionally distinct, with mTOR playing a key role in cholesterol biosynthesis and myelin maintenance.

Nutritional signals rapidly activate oligodendrocyte differentiation in the adult hypothalamic median eminence

The paper shows that refeeding after fasting rapidly activates oligodendrocyte differentiation in the hypothalamic median eminence, altering extracellular matrix proteins and using mTORC1 signaling to monitor nutritional signals.