Author

Andrew S. Mendiola

Gladstone InstitutesORCID 0000-0002-2897-3299Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Approach:experimental assay· 1

Frequent Co-Authors

Ayushi AgrawaliD· 2 shared Belinda Cabriga· 2 shared Jae Kyu RyuiD· 2 shared Jorge J. PalopiD· 2 shared Katerina AkassoglouiD· 2 shared Kelli LauderdaleiD· 2 shared Maria del pilar AlzamoraiD· 2 shared Mark H. EllismaniD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Ayushi AgrawalORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome by blocking fibrin-induced microglia activation in Alzheimers disease

Zhaoqi Yan, Andrew S. Mendiola, Kelli Lauderdale, Keun-Young Kim, Yu Yong, Kun Leng, Eric A. Bushong, Renaud Schuck, Anke Meyer‐Franke, Ayushi Agrawal, Michela Traglia, Natalie Gill, Reuben Thomas, Jonah N. Keller, Nikolaos Karvelas, , Katerina Akassoglou

This study shows that blocking fibrin-induced microglia activation reduces neuronal hyperactivity and restores the neuroimmune interactome in Alzheimer's disease.

bioRxiv · Jun 26, 2026 · PreprintNeuroscience

Therapeutic targeting of fibrin-microglia interactions ameliorates Alzheimer disease-related hyperexcitability and brain network dysfunction

Kelli Lauderdale, Zhaoqi Yan, Andrew S. Mendiola, Yutong Zhang, Dakota D. Mallen, Pranav Nambiar, Erica S Brady, Stephanie R. Miller, Rosa Meza-Acevedo, Belinda Cabriga, Xueqiao Jiang, Nick Kaliss, Kevin Shen, Jia Shin, Jessica Herbert, , Jorge J. Palop

This study shows that blocking fibrin-microglia interactions reduces AD-related brain network dysfunction and behavioral issues in mice.

bioRxiv · May 6, 2026 · PreprintNeuroscience

Microglial CX3CR1I249/M280 variant limits neurogenesis and remyelination in cuprizone-induced multiple sclerosis model

Andrew S. Mendiola, Kaira A. Church, Sandra M. Cardona, Difernando Vanegas, Shannon A. Garcia, Wendy B. Macklin, Sérgio A. Lira, Richard M. Ransohoff, Erzsebet Kokovay, Chin‐Hsing Annie Lin, Astrid E. Cardona

This study shows that the hCX3CR1I249/M280 variant impairs microglial function, reducing neurogenesis and remyelination in a multiple sclerosis model.

bioRxiv · Jun 6, 2021 · PreprintNeuroscience