DOT1L inhibition reveals a distinct class ofenhancers dependent on H3K79 methylation
Laura Godfrey, Nicholas T. Crump, Ross Thorne, I‐Jun Lau, Emmanouela Repapi, Dimitra Dimou, Alastair Smith, Joe R. Harman, Jelena M. Telenius, A. Marieke Oudelaar, Damien J. Downes, Paresh Vyas, Jim R. Hughes, Thomas A. Milne
The paper identifies a distinct class of enhancers in leukemia cells that depend on H3K79 methylation and shows that DOT1L inhibition disrupts their function.
Nature Communications · Jun 26, 2019Peer-reviewedMolecular Biology