Author

I‐Jun Lau

University of OxfordORCID 0000-0003-1727-3243Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Alastair SmithiD· 2 shared Jim R. HughesiD· 2 shared Joe R. HarmaniD· 2 shared Nicholas T. CrumpiD· 2 shared Paresh VyasiD· 2 shared Thomas A. MilneiD· 2 shared A. Marieke OudelaariD· 1 shared Damien J. DownesiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Alastair SmithORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintApr 16, 2025

Sustained MYB activity drives emergent enhancer activation and precise enhancer-promoter interactions

I‐Jun Lau, Joe R. Harman, Alastair Smith…·Thomas A. Milne

This study shows that MYB activity sustains enhancer-promoter interactions and transcription by maintaining enhancer function in leukemia.

DOI 10.1101/2025.04.16.649256

𝕏 PostBluesky

Molecular BiologyNature CommunicationsPeer-reviewedJun 26, 2019

DOT1L inhibition reveals a distinct class ofenhancers dependent on H3K79 methylation

Laura Godfrey, Nicholas T. Crump, Ross Thorne…·Thomas A. Milne

The paper identifies a distinct class of enhancers in leukemia cells that depend on H3K79 methylation and shows that DOT1L inhibition disrupts their function.

151 citationstop 2%

𝕏 PostBluesky