Sex differences in human IgG1-mediated angiogenesis inhibition depend on Y chromosome-encoded DDX3Y
Dionne A. Argyle, Roshni Dholkawala, Ryan D. Makin, Felipe Pereira, Yosuke Nagasaka, Peirong Huang, Shao-Bin Wang, Ivana Apicella, Abhinav Arneja, Chance John Luckey, Kenneth Walsh, Arthur P. Arnold, Jayakrishna Ambati, Bradley D. Gelfand
This study shows that male sex-specific anti-angiogenic effects of hIgG1 depend on the Y chromosome-encoded DDX3Y gene, revealing a mechanism for sex differences in AMD.
bioRxiv · Mar 25, 2025 · PreprintPathology