Chance John Luckey

Red Blood Cell Transfusion is a Non-Canonical Immune Stimulus Characterized by the Suboptimal Induction of CD4+ T Cell Help

This study shows that RBC transfusion induces weak IgG class switching compared to vaccination, due to suboptimal T cell help, and activates T cells via a non-canonical pathway.

Engineered human lymph node stroma model for examining interstitial fluid flow and T cell egress

This study develops an engineered human lymph node stroma model to examine how interstitial fluid flow affects T cell egress and stromal cell behavior.

Sex differences in human IgG1-mediated angiogenesis inhibition depend on Y chromosome-encoded DDX3Y

This study shows that male sex-specific anti-angiogenic effects of hIgG1 depend on the Y chromosome-encoded DDX3Y gene, revealing a mechanism for sex differences in AMD.

Splenic MARCO+ marginal zone macrophages regulate rapid production of MCP-1 and KC but are dispensable for alloantibody generation in response to stored RBCs in a murine model.

This study shows splenic MARCO+ marginal zone macrophages (MZMs) enhance cytokine production but are not required for anti-RBC alloantibody generation after stored RBC transfusion in mice.

Transfusion of allogenic murine HOD red blood cells preferentially induces low-affinity, short-lived IgG antibodies that are germinal center independent

Initiation of primary T cell--B cell interactions and early antibody responses in an organized microphysiological model of the human lymph node

This study develops an in vitro lymph node microphysiological system to model early T cell-B cell interactions and antibody responses using primary human lymphocytes.