Arthur P. Arnold

Gonadal and chromosomal sex independently and synergistically modulate innate and adaptive immune responses to implanted scaffolds

This study shows gonadal and chromosomal sex independently and together affect immune responses to implanted scaffolds in mice.

Sex chromosome and gonadal regulation of cardiac myofibroblast activation decoupled using mechanically tunable hydrogels and the Four Core Genotypes model

This study decouples the effects of sex chromosomes and gonadal sex on cardiac myofibroblast activation using FCG mice and hydrogel cultures, revealing sex-specific gene and protein expression patterns.

Sex chromosomes and sex hormones contribute jointly and independently to sex biases in cardiac development.

The paper investigates how sex chromosomes and gonadal hormones jointly and independently influence sex-biased gene expression in cardiac development across multiple stages.

Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and more

The paper develops rat models with modified sex chromosomes to study sex differences in physiology and disease by comparing XX vs. XY and varying X/Y chromosome numbers.

Gonadal and sex chromosomal contributions to sex differences in mammalian brain organization

The paper quantifies gonadal and sex chromosome dosage contributions to sex differences in brain volume across multiple regions in mice, revealing their combined effects on anatomical and cellular gene expression.

Relative contribution of gonads and sex chromosomes to sex differences in cell-type gene expression in the mouse medial septum and sex-biased disease risk

The paper investigates the relative impact of gonads and sex chromosomes on sex differences in gene expression in the mouse medial septum and links these differences to sex-biased human diseases.

Mechanisms of sex differences in acute and long COVID sequelae in mice

This study identifies sex differences in long COVID sequelae in mice, showing that X-linked genes like Xist and Tlr7 contribute to persistent inflammation and cognitive impairments in females.

Sex differences in human IgG1-mediated angiogenesis inhibition depend on Y chromosome-encoded DDX3Y

This study shows that male sex-specific anti-angiogenic effects of hIgG1 depend on the Y chromosome-encoded DDX3Y gene, revealing a mechanism for sex differences in AMD.

Four-Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage

The paper identifies an X-Y translocation in Four-Core Genotypes mice that increases Tlr7 expression and affects genetic interpretation.

A cross-species study of sex chromosome dosage effects on mammalian brain anatomy

This study compares the effects of sex chromosome trisomies on brain anatomy in humans and mice, finding species-specific patterns and some conserved regional impacts.

Relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in tissue gene regulation

The paper investigates the relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in gene regulation in liver and adipose tissues using the FCG mouse model.

Gonadal hormones and sex chromosome complement differentially contribute to ethanol intake, preference, and relapse-like behavior in Four Core Genotypes mice

This study shows that in FCG mice, sex hormones and sex chromosomes independently influence ethanol consumption, preference, and relapse-like behavior.

Cardiac Sex Differences are Established Prior to Gonad Formation

The paper identifies sex-specific transcriptomes and proteomes in cardiac tissue, showing that sex differences are established before gonad formation through post-transcriptional mechanisms and hormonal/sex chromosomal factors.

Single cell profiling of the VMH reveals a sexually dimorphic regulatory node of energy expenditure

The paper identifies six distinct neuron clusters in the VMH using single-cell RNA sequencing and shows sex-specific differences in gene expression and function related to energy expenditure.