Sequence-dependent binding modes of INO80 control +1 nucleosome positioning
Mariia Likhodeeva, Annika Brem, Alberto López-Francos, Drin Shabani, Franziska Därr, Dirk Kostrewa, Katja Lammens, Manuela Moldt, Olga Fettscher, Blaine Bartholomew, Philipp Korber, Karl‐Peter Hopfner
This study shows how INO80 distinguishes DNA sequence asymmetry in the +1 nucleosome of the SWH1 gene through inhibited and active binding modes, influencing nucleosome positioning.
bioRxiv · Oct 16, 2026 · PreprintBiochemistry