Blaine Bartholomew

This study shows how INO80 distinguishes DNA sequence asymmetry in the +1 nucleosome of the SWH1 gene through inhibited and active binding modes, influencing nucleosome positioning.

This study identifies two distinct binding mechanisms of the Arp5 subunit in the INO80 chromatin remodeler, showing their differential roles in nucleosome positioning and dimer exchange.

This study identifies an RNA binding module in the SWI/SNF complex that is essential for enhancer activation and cell-type specific gene regulation during early development.

The paper introduces ProTiler, a method to identify essential protein domains from CRISPR/Cas9 tiling-sgRNA screens, finding 175 CKHS regions with high overlap to annotated domains and novel unannotated domains.