Karl‐Peter Hopfner

This study shows how INO80 distinguishes DNA sequence asymmetry in the +1 nucleosome of the SWH1 gene through inhibited and active binding modes, influencing nucleosome positioning.

A >50,000-element viral smORF library screened by growth, MHC-I, ER stress, Perturb-seq and mass spectrometry yields >2,000 active microproteins and shows EBV BNLF2b inhibits PKA by mimicry.

This study uses HS-AFM to visualize coiled coil dynamics in MR complexes, revealing power-law scaling and long relaxation times due to internal friction.

This study shows human INO80 slides hexasomes as efficiently as nucleosomes and reveals structural mechanisms for topology-driven chromatin remodeling.

This study reveals how the chromosomal passenger complex (CPC) interacts with nucleosomes to protect centromeric chromatin, showing its non-catalytic role in maintaining chromatin stability.

This study determines cryo-EM structures of human MRN complex bound to DNA and TRF2, revealing how MRN senses DNA ends and separates sensing from nuclease activity.

This study identifies and characterizes a network of interactions between Helicobacter pylori outer membrane proteins and CagT4SS surface proteins, revealing their functional importance in transport processes.