Blood-brain barrier-traversing multivalent TGFβ trap for anti-cancer immunomodulation of gliomas
Daiheon Lee, Seung Woo Chung, Byoungjae Kong, Yunxuan Xie, 강복영, Jun Yang, Buwei Huang, Divya Rao, Jong Seob Choi, Eun A. Ra, Pavlos Anastasiadis, Gabsang Lee, Deok-Ho Kim, Michael K. Lim, Jung Soo Suk
This paper develops a TGFβ trap that crosses the blood-brain barrier to modulate the immunosuppressive tumor microenvironment and enhance immunotherapy efficacy in glioma models.
bioRxiv · Oct 6, 2026 · PreprintBioengineering