Michael K. Lim

This paper develops a TGFβ trap that crosses the blood-brain barrier to modulate the immunosuppressive tumor microenvironment and enhance immunotherapy efficacy in glioma models.

This study identifies MIRO1 as a context-specific modulator of BAX activity, showing it drives distinct cell death pathways in glioma cells and Parkinsonian neurons through different mechanisms.

The paper integrates cross-species transcriptomic data to identify a MIRO1-mediated macrophage-T cell axis in glioma that contributes to immunosuppression.

The paper uses patient-derived organoids to study TAM responses to CD47 checkpoint blockade, revealing a conversion to an immunosuppressive SPP1+ phenotype in clear cell renal cell carcinoma.

This study identifies the immunosuppressive cellular and genomic features of colorectal cancer brain metastases and their mechanisms of adaptation.

This study examines how dual checkpoint blockade with Anti-PD-1 and Anti-LAG-3 affects T cell clones in glioblastoma, showing increased clonal expansion and differentiation into effector T cells.