EGF signalling in epithelial carcinoma cells utilizes preformed receptor homoclusters, with larger heteroclusters post activation
Charlotte Fournier, Adam J. M. Wollman, Isabel Llorente-Garcia, Oliver Harriman, Djamila Ouarat, Jenny Wilding, Walter Bodmer, Mark C. Leake
This study uses single-molecule tracking to show EGFR homoclusters pre-activate and form heteroclusters with HER2 after EGF binding, with a peak EGFR-to-EGF ratio of 2.
bioRxiv · Apr 20, 2018 · PreprintBiophysics