EGF signaling in bowel carcinoma cells utilizes higher order architectures of EGFR and HER2
Adam Wollman, Charlotte Fournier, Isabel Llorente-Garcia, Oliver Harriman, Alex Hargreaves, Sviatlana Shashkova, Peng Zhou, Djamila Ouret, Jenny Wilding, Ta-Chun Liu, Akihiro Kusumi, Walter F Bodmer, Mark C Leake
This study uses single-molecule imaging to show that EGF signaling in carcinoma cells involves EGFR and HER2 clusters with increased stoichiometry after EGF activation.
bioRxiv · Jul 11, 2020 · PreprintBiophysics