Mitochondrial Signatures Shape Phenotype Switching and Apoptosis in Response to PLK1 and RSK Inhibitors in Melanoma
Emilie Lavallée, Maëline Roulet-Matton, Viviane Giang, Roxana Cardona Hurtado, Dominic Chaput, Simon‐Pierre Gravel
The paper identifies mitochondrial protein signatures that determine sensitivity to PLK1 inhibitors in melanoma, showing that mitochondrial DNA depletion and ABCD1 silencing enhance sensitivity and reduce pro-inflammatory responses.
Life Science Alliance · Dec 10, 2024Peer-reviewedCancer Biology