Simon‐Pierre Gravel

This study shows that the CD36 modulator MPE-298 reduces infarct size and LCFA accumulation in mice after myocardial ischemia-reperfusion.

This study identifies an early IKKβ-dependent anabolic signature in vascular smooth muscle cells that drives abdominal aortic aneurysm development.

The paper identifies mitochondrial protein signatures that determine sensitivity to PLK1 inhibitors in melanoma, showing that mitochondrial DNA depletion and ABCD1 silencing enhance sensitivity and reduce pro-inflammatory responses.

Screening of a mRNA-LNPs library yielded a formulation with outmost potency and mitigated the progression of LAL deficiency in a preclinical model.

This paper identifies ATP5I as a target of metformin, showing its role in mediating metabolic and antiproliferative effects through mitochondrial dysfunction and altered ATP synthase oligomerization.