Deconstructing replicative senescence heterogeneity of human mesenchymal stem cells at single cell resolution reveals therapeutically targetable senescent cell sub-populations
Atefeh Taherian Fard, Hannah C. Leeson, Julio Aguado, Giovanni Pietrogrande, Dominique Power, Cecilia Liliana Gomez Inclan, Huiwen Zheng, Christopher B. Nelson, Mohammad Soheilmoghaddam, Nick R. Glass, Malindrie Dharmaratne, Ebony Rose Watson, Jennifer Lu, Sally Martin, Hilda A. Pickett, , Jessica C. Mar
This study identifies three distinct senescent subpopulations in human mesenchymal stem cells using single-cell RNA sequencing, revealing potential drug targets for senescence delay.
bioRxiv · Jan 24, 2022 · PreprintBioinformatics