Hilda A. Pickett

MUTYH activity maintains telomere stability in response to chronic telomeric 8-oxoguanine damage in cancer cells

This study shows MUTYH prevents telomere shortening and genomic instability in cancer cells under chronic 8-oxoG damage by resolving BER intermediates.

Anillin-dependent actin assembly at PML NBs protects genome stability

The paper shows that Anillin-dependent actin assembly at PML NBs protects genome stability by shielding under-replicated DNA across cell cycles.

Potent synthetic lethality between PLK1 and EYA-family inhibitors in tumours of the central and peripheral nervous system

This study shows that combining EYA and PLK1 inhibitors is effective in treating neurological cancers by inducing cell death and targeting cancer stem cells.

Homologous recombination promotes mitotic death to suppress the innate immune response

The paper shows that homologous recombination (HR) promotes mitotic death, which suppresses the innate immune response by preventing immunogenic cell death.

Mechanism of structure-specific DNA binding by the FANCM branchpoint translocase

This study identifies the Hel2i domain as essential for FANCM's DNA binding and branch migration, revealing its role in suppressing the ALT pathway in cancer cells.

Replication stress tolerance and management differs between naive and primed pluripotent cells

The paper compares replication stress management in naive and primed pluripotent mouse cells, finding that primed cells use Atr to prevent genomic damage, while naive cells activate Atm and undergo apoptosis.

Deconstructing replicative senescence heterogeneity of human mesenchymal stem cells at single cell resolution reveals therapeutically targetable senescent cell sub-populations

This study identifies three distinct senescent subpopulations in human mesenchymal stem cells using single-cell RNA sequencing, revealing potential drug targets for senescence delay.

The Medical Genome Reference Bank: Whole genomes and phenotype of 2,570 healthy elderly

The paper introduces the Medical Genome Reference Bank, a resource of whole genome sequences and phenotypes from 2,570 healthy elderly Australians, showing fewer disease-associated variants and age-related somatic changes linked to grip strength.

Telomere-loop dynamics in chromosome end protection

The paper investigates telomere-loop dynamics in chromosome end protection using super-resolution microscopy and finds that t-loops act as conformational switches regulating ATM activation independent of telomere fusion.