Giovanni Pietrogrande

Interaction of Gut-Microbial Amyloids with Endogenous Amyloids can Drives Microglial Hyperactivity and Neuroinflammation in Alzheimers Disease

The paper shows microbial amyloids from gut pathogens can trigger microglial hyperactivity and neuroinflammation, contributing to Alzheimer's disease progression.

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.

This study shows senolytic drugs reduce brain aging and COVID-19-related neuropathology by targeting senescent cells in human brain organoids and mice.

Rapamycin mitigates Valproic Acid-induced teratogenicity in human and animal models by suppressing AP-1-mediated senescence

This study shows that rapamycin reduces VPA-induced teratogenic effects by suppressing AP-1-mediated senescence in human and zebrafish models.

Deconstructing replicative senescence heterogeneity of human mesenchymal stem cells at single cell resolution reveals therapeutically targetable senescent cell sub-populations

This study identifies three distinct senescent subpopulations in human mesenchymal stem cells using single-cell RNA sequencing, revealing potential drug targets for senescence delay.

Low oxygen post conditioning improves stroke-induced cognitive impairment

This study shows that low oxygen post conditioning reduces amyloid-beta levels and improves cognitive function in mice after stroke.