Christopher B. Nelson

Anillin-dependent actin assembly at PML NBs protects genome stability

The paper shows that Anillin-dependent actin assembly at PML NBs protects genome stability by shielding under-replicated DNA across cell cycles.

Potent synthetic lethality between PLK1 and EYA-family inhibitors in tumours of the central and peripheral nervous system

This study shows that combining EYA and PLK1 inhibitors is effective in treating neurological cancers by inducing cell death and targeting cancer stem cells.

Homologous recombination promotes mitotic death to suppress the innate immune response

The paper shows that homologous recombination (HR) promotes mitotic death, which suppresses the innate immune response by preventing immunogenic cell death.

Replication stress tolerance and management differs between naive and primed pluripotent cells

The paper compares replication stress management in naive and primed pluripotent mouse cells, finding that primed cells use Atr to prevent genomic damage, while naive cells activate Atm and undergo apoptosis.

Deconstructing replicative senescence heterogeneity of human mesenchymal stem cells at single cell resolution reveals therapeutically targetable senescent cell sub-populations

This study identifies three distinct senescent subpopulations in human mesenchymal stem cells using single-cell RNA sequencing, revealing potential drug targets for senescence delay.

Telomeric Double Strand Breaks Facilitate Formation of 5' C-Rich Overhangs in G1 Human Cells

The paper investigates the cellular response to telomeric double-strand breaks in G1 phase human cells, finding that they lead to 5' C-rich overhangs associated with the ALT pathway.