Sphingosine-1-phosphate receptor modulators resensitize FLT3-ITD acute myeloid leukemia cells with NRAS mutations to FLT3 inhibitors
Aditi Chatterjee, Moaath K. Mustafa Ali, Christopher M. Bailey, Yuchen Liu, Donald Small, Catherine Choy Smith, Elie A. Traer, Yin Wang, Giovannino Silvestri, Maria R. Baer
This study shows that S1P receptor modulators resensitize NRAS-mutated FLT3-ITD AML cells to FLT3 inhibitors by inhibiting downstream signaling pathways.
Leukemia · Jun 2, 2026Peer-reviewedCancer Biology