Yuchen Liu

LuTuFlow: a deep learning-based pipeline for quantitative characterization of mouse lung tumors in CT imaging

LuTuFlow automates mouse lung tumor analysis in CT scans by integrating deep learning for segmentation and tracking, providing quantitative results and visualizations.

ctDNA Release Heterogeneity in Luminal Breast Cancer Revealed by Single-Cell Multi-Omics Spatial Analysis

The paper identifies cellular and spatial determinants of ctDNA release in HR+/HER2- breast cancer using single-cell multi-omics spatial analysis, linking tumor states, mutations, and immune interactions to ctDNA release patterns.

Regulatory-scale stripe analysis from single-cell Hi-C with scStripe

scStripe detects and quantifies chromatin stripes in single-cell Hi-C data, resolving cell-type-specific regulatory features and capturing genome-wide variation.

Genetically Programmed Shape-morphing of Engineered Living Materials

This paper demonstrates genetically programmed shape-morphing in engineered living materials using enzymatic reactions to control hydrogel properties and motion.

Sphingosine-1-phosphate receptor modulators resensitize FLT3-ITD acute myeloid leukemia cells with NRAS mutations to FLT3 inhibitors

This study shows that S1P receptor modulators resensitize NRAS-mutated FLT3-ITD AML cells to FLT3 inhibitors by inhibiting downstream signaling pathways.

Self-Terminating Bilayer Hydrogel Actuators via Enzyme-Programmed Mechanical Feedback

This paper introduces a bilayer hydrogel actuator that uses enzyme-programmed mechanical feedback to achieve self-regulated shape transformation and autonomous recovery.

Spatial and single-cell expression analyses reveal complex expression domains in early wheat spike development

Combining 99-gene smFISH across 48,225 cells with scRNA-seq of 26,009 cells maps 21 spatial expression domains and imputes 74,464 genes in early tetraploid wheat spikes.

SCRIPT: Predicting Single-cell Long-range Cis-regulation Based on Pretrained Graph Attention Networks

SCRIPT predicts single-cell cis-regulatory relationships using graph attention networks, achieving high accuracy and improving long-range prediction.

The population genetics of Strongyloides papillosus in Pakistani goats revealed by whole genome sequencing

This study uses whole genome sequencing to analyze the population genetics of S. papillosus in Pakistani goats, revealing high prevalence, genetic diversity, and mixed-genotype infections with limited admixture.

Transcript errors generate a continuous stream of amyloid and prion-like proteins in human cells

The paper shows transcript errors generate amyloid and prion-like proteins in human cells, linking DNA damage to aging and disease.