Analysis of crosslinking sites suggests C. elegnas PIWI Argonaute exhibits flexible conformations for target recognition
Wei Wu, Dong-En Lee, Chi-Jung Chung, Shang-Yi Lu, Jordan S. Brown, Donglei Zhang, Heng-Chi Lee
The paper develops MUTACLASH to analyze CIMs in CLASH data, revealing that CIMs are enriched at piRNA/miRNA target sites and suggest flexible conformations of PRG-1 for target recognition.
bioRxiv · Feb 14, 2025 · PreprintMolecular Biology